PROFIL PASIEN SPONDILITIS TUBERKULOSIS DI RSPAL DR. RAMELAN PERIODE JANUARI 2024-DESEMBER 2025

Nadya Aisyah Sasqia Putri; Rifda  Irfada; Izah  Nabila Dwi Mardhiyani; Claudya  Herlenay Rafael; Muhammad Shobrian; Janto Poernomo Hadi; Adi  Suriyanto

doi:10.30649/v6i1.198

Authors

Nadya Aisyah Sasqia Putri Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia
Rifda Irfada Faculty of Medicine, Hang Tuah Unviersity, Surabaya,Indonesia
Izah Nabila Dwi Mardhiyani Faculty of Medicine, Hang Tuah Unviersity, Surabaya,Indonesia
Claudya Herlenay Rafael Faculty of Medicine, Hang Tuah Unviersity, Surabaya,Indonesia
Muhammad Shobrian Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia
Janto Poernomo Hadi Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Hang Tuah, Surabaya, Indonesia., Indonesia
Adi Suriyanto Departement of Orthopaedics and Traumatology, Ramelan Central Naval Hospital, Faculty of Medicine Hang Tuah University,Surabaya,Indonesia

DOI:

https://doi.org/10.30649/v6i1.198

Keywords:

spondilitis tuberkulosis, profil pasien, nyeri punggung, defisit neurologis, tata laksana

Abstract

Latar Belakang: Latar Belakang: Spondilitistuberkulosis merupakan bentuk tuberkulosisekstraparu yang mengenai tulang belakang dan dapatmenyebabkan nyeri punggung kronik, destruksivertebra, deformitas spinal, hingga defisit neurologis. Gambaran profil pasien penting diketahui sebagai data dasar untuk memahami karakteristik klinis pasienspondilitis tuberkulosis yang dirawat inap.

Tujuan: Mengetahui profil pasien spondilitistuberkulosis yang dirawat inap di RSPAL dr. Ramelan periode Januari 2024–Desember 2025 berdasarkanusia, jenis kelamin, keluhan klinis utama, lokasi lesivertebra, defisit neurologis, tata laksana, dan outcome.

Metode: Penelitian ini merupakan penelitiandeskriptif retrospektif menggunakan data sekunderdari rekam medis pasien spondilitis tuberkulosis yang dirawat inap di RSPAL dr. Ramelan periode Januari 2024–Desember 2025. Sampel penelitian diambilmenggunakan teknik total sampling sesuai kriteriainklusi dan eksklusi. Data dianalisis secara deskriptifmenggunakan distribusi frekuensi dan persentase.

Hasil: Didapatkan 55 pasien yang memenuhi kriteriapenelitian. Kelompok usia terbanyak adalah 18–40 tahun sebanyak 26 pasien (47,3%). Pasien perempuanlebih banyak dibandingkan laki-laki, yaitu 34 pasien(61,8%). Keluhan klinis utama terbanyak adalah nyeripunggung sebanyak 36 pasien (65,5%). Lokasi lesivertebra terbanyak adalah regio torakal sebanyak 21 pasien (38,2%), diikuti regio lumbal sebanyak 20 pasien (36,4%). Defisit neurologis ditemukan pada 32 pasien (58,2%). Seluruh pasien mendapatkan tata laksana kombinasi obat antituberkulosis dan operasisebanyak 55 pasien (100%). Outcome terbanyakadalah membaik sebanyak 53 pasien (96,3%), sedangkan 2 pasien (3,7%) meninggal.

Kesimpulan: Profil pasien spondilitis tuberkulosisyang dirawat inap di RSPAL dr. Ramelan periodeJanuari 2024–Desember 2025 didominasi oleh kelompok usia produktif, jenis kelamin perempuan, keluhan utama nyeri punggung, lokasi lesi torakal, disertai defisit neurologis pada sebagian besar pasien, mendapatkan kombinasi obat antituberkulosis dan operasi, serta sebagian besar memiliki outcome membaik saat keluar dari rumah sakit.

References

Agrawal, V., Patgaonkar, P.R. and Nagariya, S.P. (2010) ‘Tuberculosis of spine’, Journal of Craniovertebral Junction and Spine, 1(2), pp. 74–85. Available at: https://doi.org/10.4103/0974-8237.77671 .

Agulló-Ros, I., Moreno-Iruela, I., Domínguez, M., Gómez-Villamandos, J.C. and Risalde, M.A. (2025) ‘Immunopathogenesis of tuberculosis: cellular mechanisms and immune modulation’, Veterinary Research, 57, article 21. Available at: https://doi.org/10.1186/s13567-025-01670-1 .

Athiyyah, S.N., Sahputra, R.E. and Reza, M. (2024) ‘Characteristics of Tuberculous Spondylitis Patients at Dr. M. Djamil Padang Hospital 2018–2020’, Frontiers on Healthcare Research, 1(2), pp. 64–69. Available at: https://doi.org/10.63918/fhr.v1.n2.p64-69.2024 .

Biakto, K.T., Kusmawan, I.G.P.Y., Massi, M.N., Usman, M.A. and Arifin, J. (2024) ‘Diagnostic accuracy of GeneXpert in the diagnosis of spinal tuberculosis: a systematic review and meta-analysis’, Narra J, 4(2), article e925. Available at: https://doi.org/10.52225/narra.v4i2.925 .

Brotoarianto, H.K., Risdianto, A., Bakhtiar, Y., Kamil, M. and Arifin, M.T. (2024) ‘Epidemiology and diagnostic tools practice of spinal tuberculosis at Kariadi Hospital Semarang, Indonesia’, Indonesia Journal of Biomedical Science, 18(1), pp. 123–126. Available at: https://doi.org/10.15562/ijbs.v18i1.560 .

Desenia, A.P., Fauzi, A., Triyandi, R. and Rahmayani, F. (2023) ‘Spondilitis Tuberkulosis: Epidemiologi, Diagnosis, Tatalaksana, dan Prognosis’, Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine, 9(1), pp. 5–14. Available at: https://juke.kedokteran.unila.ac.id/index.php/agro/article/view/3077 .

Gan, J., Zhang, C., Tang, D. and Du, X. (2024) ‘Surgical treatment of spinal tuberculosis: an updated review’, European Journal of Medical Research, 29, article 588. Available at: https://doi.org/10.1186/s40001-024-02198-4 .

Garg, D. and Goyal, V. (2020) ‘Spinal tuberculosis treatment: an enduring bone of contention’, Annals of Indian Academy of Neurology, 23(4), pp. 441–448. Available at: https://doi.org/10.4103/aian.AIAN_141_20 .

Glassman, I., Nguyen, K.H., Giess, J., Alcantara, C., Booth, M. and Venketaraman, V. (2023) ‘Pathogenesis, diagnostic challenges, and risk factors of Pott’s disease’, Clinical Practice, 13(1), pp. 155–165. Available at: https://doi.org/10.3390/clinpract13010014 .

Handryastuti, S., Kaswandani, N., Hendriarto, A., Tobing, S.D.A.L., Pebriansyah, P. and Rafli, A. (2024) ‘Clinical manifestations and prognosis of tuberculous spondylitis in an adolescent with disseminated tuberculosis: a case report’, Paediatrica Indonesiana, 64(2), pp. 176–183. Available at: https://doi.org/10.14238/pi64.2.2024.176-83 .

Imran, M., Alshrari, A.S., Khan, A. and Alzahrani, A.R. (2025) ‘IFN-γ-driven macrophage responses in the immunity to Mycobacterium tuberculosis and Mycobacterium leprae’, Frontiers in Cellular and Infection Microbiology, 15, article 1679691. Available at: https://doi.org/10.3389/fcimb.2025.1679691 .

Isbaniah, F., Burhan, E., Sinaga, B.Y.M., Behtri, D., Yanifitri, Handayani, D., Harsini, Agustin, H., Artika, I.N., Aphridasari, J., Lasmaria, R., Russilawati, Soedarsono and Sugiri, Y.J.R. (2021) Tuberkulosis: Pedoman Diagnosis dan Penatalaksanaan di Indonesia. 2nd edn. Jakarta: Perhimpunan Dokter Paru Indonesia.

Issack, P.S. and Boachie-Adjei, O. (2012) ‘Surgical correction of kyphotic deformity in spinal tuberculosis’, International Orthopaedics, 36(2), pp. 353–357. Available at: https://doi.org/10.1007/s00264-011-1292-9 .

Kandwal, P., Garg, B., Upendra, B.N., Chowdhury, B. and Jayaswal, A. (2012) ‘Outcome of minimally invasive surgery in the management of tuberculous spondylitis’, Indian Journal of Orthopaedics, 46(2), pp. 159–164. Available at: https://doi.org/10.4103/0019-5413.93680 .

Kementerian Kesehatan Republik Indonesia (2023) Petunjuk Teknis Tata Laksana Tuberkulosis Anak dan Remaja. Jakarta: Kementerian Kesehatan Republik Indonesia.

Khanna, K. and Sabharwal, S. (2019) ‘Spinal tuberculosis: a comprehensive review for the modern spine surgeon’, The Spine Journal, 19(11), pp. 1858–1870. Available at: https://doi.org/10.1016/j.spinee.2019.05.002 .

Leowattana, W., Leowattana, P. and Leowattana, T. (2023) ‘Tuberculosis of the spine’, World Journal of Orthopedics, 14(5), pp. 275–293. Available at: https://doi.org/10.5312/wjo.v14.i5.275 .

Lewinsohn, D.M., Leonard, M.K., LoBue, P.A., Cohn, D.L., Daley, C.L., Desmond, E., Keane, J., Lewinsohn, D.A., Loeffler, A.M., Mazurek, G.H., O’Brien, R.J., Pai, M., Richeldi, L., Salfinger, M., Shinnick, T.M., Sterling, T.R., Warshauer, D.M. and Woods, G.L. (2017) ‘Official ATS/IDSA/CDC Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children’, Clinical Infectious Diseases, 64(2), pp. e1–e33. Available at: https://doi.org/10.1093/cid/ciw694 .

Lyu, J., Narum, D.E., Baldwin, S.L., Larsen, S.E., Bai, X., Griffith, D.E., Dartois, V., Naidoo, T., Steyn, A.J.C., Coler, R.N. and Chan, E.D. (2024) ‘Understanding the development of tuberculous granulomas: insights into host protection and pathogenesis, a review in humans and animals’, Frontiers in Immunology, 15, article 1427559. Available at: https://doi.org/10.3389/fimmu.2024.1427559 .

Mak, K.C. and Cheung, K.M.C. (2013) ‘Surgical treatment of acute TB spondylitis: indications and outcomes’, European Spine Journal, 22(Suppl 4), pp. 603–611. Available at: https://doi.org/10.1007/s00586-012-2455-0 .

Moon, M.S. (2014) ‘Tuberculosis of spine: current views in diagnosis and management’, Asian Spine Journal, 8(1), pp. 97–111. Available at: https://doi.org/10.4184/asj.2014.8.1.97 .

Moore, K.L., Dalley, A.F. and Agur, A.M.R. (2014) Clinically Oriented Anatomy. 7th edn. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins.

Oguz, E., Sehirlioglu, A., Altinmakas, M., Ozturk, C., Komurcu, M., Solakoglu, C. and Vaccaro, A.R. (2008) ‘A new classification and guide for surgical treatment of spinal tuberculosis’, International Orthopaedics, 32(1), pp. 127–133. Available at: https://doi.org/10.1007/s00264-007-0398-8 .

Öztürk, A.M., Yener, C. and Taşbakan Işıkgöz, M. (2020) ‘Current concepts on spinal tuberculosis’, Journal of Turkish Spinal Surgery, 31(1), pp. 60–63. Available at: https://doi.org/10.4274/jtss.galenos.2020.31 .

Rajasekaran, S., Soundararajan, D.C.R., Shetty, A.P. and Kanna, R.M. (2018) ‘Spinal Tuberculosis: Current Concepts’, Global Spine Journal, 8(4 Suppl), pp. 96S–108S. Available at: https://doi.org/10.1177/2192568218769053 .

Ross, V.M.S., Pinzón, B., Palacios-Ortiz, D.M., De La Rosa-Noriega, Z., Rafeh, J.A. and Jurado, L.F. (2025) ‘Spinal tuberculosis, pathophysiology and radiological presentation, three case reports’, Biomédica, 45(4), pp. 511–520. Available at: https://doi.org/10.7705/biomedica.7685 .

Sahputra, R.E. and Munandar, I. (2015) ‘Laporan kasus spondilitis tuberkulosa cervical’, Jurnal Kesehatan Andalas, 4(2), pp. 639–648.

Shanmuganathan, R., Ramachandran, K., Shetty, A.P. and Kanna, R.M. (2023) ‘Active tuberculosis of spine: current updates’, North American Spine Society Journal, 16, article 100267. Available at: https://doi.org/10.1016/j.xnsj.2023.100267 .

World Health Organization (2025) WHO consolidated guidelines on tuberculosis: module 4: treatment - drug-susceptible tuberculosis treatment. Geneva: World Health Organization. Available at: https://www.who.int/publications/i/item/9789240098698 .

World Health Organization (2026) Tuberculosis. Available at: https://www.who.int/news-room/fact-sheets/detail/tuberculosis .